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Clonidine Patch and Gengraf Capsules

Determining the interaction of Clonidine Patch and Gengraf Capsules and the possibility of their joint administration.

Check result:

Clonidine Patch <> Gengraf Capsules

Relevance: 15.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with cloNIDine may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: A single case has been reported in which whole-blood cyclosporine levels rose significantly and abruptly after the addition of clonidine and decreased after discontinuation of clonidine. Transdermal clonidine has also been associated with increases in cyclosporine levels. The mechanism is unknown. In addition, it has been suggested that clonidine may have a beneficial effect in preventing cyclosporine-induced nephrotoxicity. The mechanism is unknown and data have been conflicting.

MANAGEMENT: Until more information is available, frequent monitoring of whole-blood cyclosporine levels and renal function is recommended. Patients should be advised to notify their physician if they experience symptoms of possible cyclosporine toxicity, such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

Luke J, Luke DR, Williams LA, LeMaistre CF, Yau JC "Prevention of cyclosporine-induced nephrotoxicity with transdermal clonidine." Clin Pharm 9 (1990): 49-53
Gilbert RD, Rahn D, Cassidy M "Interaction between clonidine and cyclosporine A." Nephron 71 (1995): 105

Clonidine Patch

Generic Name: clonidine

Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3

Synonyms: Clonidine, CloNIDine

What is Clonidine Patch?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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