Clonidine Patches and Lidocaine and Epinephrine Injection
Determining the interaction of Clonidine Patches and Lidocaine and Epinephrine Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Clonidine prolongs the duration of lidocaine anesthesia in peripheral and central neuraxial blocks. Data have been conflicting as to whether the mechanism is pharmacokinetic or pharmacodynamic.
- Kopacz DJ, Bernards CM "Effect of Clonidine on Lidocaine Clearance In Vivo: A Microdialysis Study in Humans." Anesthesiology 95 (2001): 1371-1376
- Inomata S, Tanaka E, Miyabe M, et al. "Plasma Lidocaine Concentrations During Continuous Thoracic Epidural Anesthesia After Clonidine Premedication in Children." Anesth Analg 93 (2001): 1147-1151
Generic Name: clonidine
Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Clonidine, CloNIDine
Generic Name: epinephrine / lidocaine
Brand name: D-Care 100X, Lignospan Forte, Lignospan Standard, Xylocaine MPF With Epinephrine, Xylocaine With Epinephrine
Synonyms: Lidocaine and Epinephrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonidine Patches-Lidocaine and Hydrocortisone Cream
- Clonidine Patches-Lidocaine and Hydrocortisone Gel
- Clonidine Patches-Lidocaine and Hydrocortisone Rectal Cream
- Clonidine Patches-Lidocaine and Hydrocortisone Rectal Cream and Gel
- Clonidine Patches-Lidocaine and hydrocortisone Topical application, Rectal
- Clonidine Patches-Lidocaine and Menthol
- Lidocaine and Epinephrine Injection-Clonidine Tablets
- Lidocaine and Epinephrine Injection-Clonidine transdermal
- Lidocaine and Epinephrine Injection-Clopidogrel
- Lidocaine and Epinephrine Injection-Clopidogrel Bisulfate
- Lidocaine and Epinephrine Injection-Clorazepate
- Lidocaine and Epinephrine Injection-Clorazepate Dipotassium