Clonidine Tablets and Duragesic-100 skin patch
Determining the interaction of Clonidine Tablets and Duragesic-100 skin patch and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One study has suggested that clonidine may markedly reduce the fentanyl dosage required for prevention of hyperdynamic cardiovascular responses to laryngoscopy and intubation. The authors proposed that synergistic inhibitory actions of opiates and alpha-2-adrenoreceptor agonists on central sympathetic outflow may have accounted for reduced fentanyl requirement.
- Rostaing S, Bonnet F, Levron JC, et al "Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients." Anesthesiology 75 (1991): 420-5
- Ghignone M, Quintin L, Duke PC, Kehler CH, Calvillo O "Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation." Anesthesiology 64 (1986): 36-42
- Murga G, Samso E, Valles J, Casanovas P, Puig MM "The effect of clonidine on intra-operative requirements of fentanyl during combined epidural/general anaesthesia." Anaesthesia 49 (1994): 999-1002
Generic Name: clonidine
Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Clonidine, CloNIDine
Generic Name: fentanyl
Brand name: Duragesic, Abstral, Fentora, Subsys, Actiq, Ionsys, Lazanda, Onsolis, Sublimaze
Synonyms: Duragesic Skin Patch, Duragesic
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonidine Tablets-Durahist D
- Clonidine Tablets-Duramist Plus
- Clonidine Tablets-Duramorph
- Clonidine Tablets-Duramorph PF injection
- Clonidine Tablets-Durapren Injection
- Clonidine Tablets-DuraProxin ES
- Duragesic-100 skin patch-Clonidine transdermal
- Duragesic-100 skin patch-Clopidogrel
- Duragesic-100 skin patch-Clopidogrel Bisulfate
- Duragesic-100 skin patch-Clorazepate
- Duragesic-100 skin patch-Clorazepate Dipotassium
- Duragesic-100 skin patch-Clorotekal