Clonidine transdermal and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CloNIDine may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar) in patients receiving TOLAZamide and certain other antidiabetic medications. In addition, cloNIDine may mask some of the symptoms of hypoglycemia such as tremor, palpitation and rapid heartbeat, making it more difficult to recognize an oncoming episode. Other symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, nausea, hunger, weakness, and perspiration are not affected. Talk to your doctor if you have any questions or concerns. You may need to monitor your blood glucose levels more frequently, especially if you are prone to developing hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Clonidine may diminish the physiological response to hypoglycemia induced by insulin and/or oral hypoglycemic agents (i.e., insulin secretagogues such as sulfonylureas and meglitinides). Clonidine inhibits the release of catecholamines, which are responsible for recovery of normal blood glucose levels and symptoms of hypoglycemia such as tremor, sweating, tachycardia, and blood pressure changes. In normal and hypertensive individuals, response to insulin-induced hypoglycemia has been shown to decrease significantly during administration of clonidine 0.45 to 0.9 mg daily. However, clonidine has also been reported to elevate plasma blood glucose and cause hyperglycemia.

MANAGEMENT: Patients should be instructed about the need for regular monitoring of blood glucose levels and be aware that certain symptoms of hypoglycemia such as tremors, sweating, and tachycardia may be reduced or absent during treatment with clonidine.

Clonidine transdermal

Generic Name: clonidine

Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3

Synonyms: Clonidine, CloNIDine

What is Clonidine transdermal?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?