Clotrimazole and Ethinyl estradiol and norethindrone birth control
Determining the interaction of Clotrimazole and Ethinyl estradiol and norethindrone birth control and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using clotrimazole and ethinyl estradiol together may alter the levels of ethinyl estradiol in your body. This combination may cause nausea, vomiting, or vaginal bleeding. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Azole antifungal agents may increase the plasma concentrations of estrogens and progestins. The mechanism is decreased clearance of the hormones due to inhibition of CYP450 3A4 activity by azole antifungals. Coadministration of voriconazole (200 mg every 12 hours) and an oral contraceptive containing 35 mcg of ethinyl estradiol and 1 mg of norethindrone increased the steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ethinyl estradiol by an average of 36% and 61%, respectively, and Cmax and AUC of norethindrone by 15% and 53%, respectively, in healthy volunteers. Fluconazole doses of 150 mg and 200 mg have also been shown to increase the serum concentrations of ethinyl estradiol and levonorgestrel in healthy women receiving low-dose oral contraceptives, while single and multiple doses of fluconazole 50 mg had no significant effect on the pharmacokinetics of a high-dose oral contraceptive containing 150 mcg ethinyl estradiol and norgestrel 300 mcg. Ironically, there have been isolated reports of breakthrough bleeding and unintended pregnancy during use of oral contraceptives with itraconazole, which would suggest decreased rather than increased effect of the contraceptives. However, the association to itraconazole is questionable.
MANAGEMENT: During concomitant therapy with azole antifungal agents, patients should be observed for increased or altered pharmacologic response to estrogens and progestins, and dosage(s) adjusted accordingly as necessary.
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Generic Name: clotrimazole
Brand name: Mycelex Troche
Synonyms: Clotrimazole (Oral)
Generic Name: ethinyl estradiol / norethindrone
Brand name: femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon
Synonyms: Ethinyl estradiol and norethindrone (HRT), Ethinyl Estradiol and Norethindrone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clotrimazole-Ethinyl Estradiol and Norethindrone Chewable Tabs & Ferrous Fumarate Tabs
- Clotrimazole-Ethinyl estradiol and norethindrone HRT
- Clotrimazole-Ethinyl Estradiol and Norethindrone Tablets
- Clotrimazole-Ethinyl estradiol and norgestimate
- Clotrimazole-Ethinyl estradiol and norgestrel
- Clotrimazole-Ethinyl estradiol and segesterone vaginal ring
- Ethinyl estradiol and norethindrone birth control-Clotrimazole (Oral)
- Ethinyl estradiol and norethindrone birth control-Clotrimazole Betamethasone Cream
- Ethinyl estradiol and norethindrone birth control-Clotrimazole Betamethasone Lotion
- Ethinyl estradiol and norethindrone birth control-Clotrimazole Lozenge
- Ethinyl estradiol and norethindrone birth control-Clotrimazole Mucous membrane, oral
- Ethinyl estradiol and norethindrone birth control-Clove