Cloxacillin Capsules and Malarone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cloxacillin together with proguanil may decrease the effects of cloxacillin. Cloxacillin and proguanil should be administered at least 1 to 2 hours apart. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: The concomitant administration of proguanil may delay as well as decrease the gastrointestinal absorption of cloxacillin. The exact mechanism of interaction is unknown but may involve adsorption of cloxacillin to proguanil in the gastrointestinal tract, formation of a complex between the two drugs, or inhibition of gastric motility by proguanil, all of which may lead to reduction in bioavailability of cloxacillin. In seven healthy volunteers, coadministration of a single oral dose of proguanil (200 mg) and cloxacillin (500 mg) resulted in an approximately 50% decrease in both the rate and extent of cloxacillin absorption compared to administration of cloxacillin alone.

MANAGEMENT: To avoid potentially subtherapeutic plasma concentrations of cloxacillin during coadministration with proguanil, the drugs should probably be administered at least 1 to 2 hours apart.

Cloxacillin Capsules

Generic Name: cloxacillin

Brand name:

Synonyms: n.a.

What is Cloxacillin Capsules?

Malarone

Generic Name: atovaquone / proguanil

Brand name: Malarone, Malarone Pediatric

Synonyms: n.a.

What is Malarone?