Clozapine and Valproic Acid Syrup
Determining the interaction of Clozapine and Valproic Acid Syrup and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Several reports have suggested that valproate may slightly increase serum clozapine levels and levels of clozapine metabolites. Increased sedation and functional impairment may result. The mechanism of this interaction has not been delineated, but may involve competitive protein binding, which may also result in an increase in valproate concentrations. In contrast, other reports imply that valproate may induce the metabolism of clozapine which would result in a reduction in clozapine plasma levels. If clozapine and valproic acid or any of its derivatives must be used together, close observation for altered clozapine effect is recommended. The clinical significance of this potential interaction is unknown; further investigation is required.
- Centorrino F, Baldessarini RJ, Kando J, et al. "Serum concentrations of clozapine and its major metabolites - effects of cotreatment with fluoxetine or valproate." Am J Psychiatry 151 (1994): 123-5
- Cerner Multum, Inc. "Australian Product Information." O 0
- Centorrino F, Baldessarini RJ, Kando JC, Frankenburg FR, Volpicelli SA, Flood JG "Clozapine and metabolites - concentrations in serum and clinical findings during treatment of chronically psychotic patients." J Clin Psychopharmacol 14 (1994): 119-25
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: CloZAPine
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic acid, Valproic Acid and Derivatives
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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