Clozapine Oral Suspension and Excedrin Tension Headache Express Gels
Determining the interaction of Clozapine Oral Suspension and Excedrin Tension Headache Express Gels and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Caffeine may increase clozapine serum concentrations and exacerbate psychotic symptoms. The mechanism is unknown but may be related to competition for the same metabolic pathway. No specific intervention is necessary; however, if an interaction is suspected it is recommended that caffeine intake be avoided.
- Hagg S, Spiset O, Mjorndal T, Dalqvist R "Effect of caffeine on clozapine pharmacokinetics in healthy volunteers." Br J Clin Pharmacol 49 (2000): 59-63
- Odom-White A, de Leon J "Clozapine levels and caffeine." J Clin Psychiatry 57 (1996): 175-6
- Vainer JL, Chouinard G "Interaction between caffeine and clozapine." J Clin Psychopharmacol 14 (1994): 284
- Carrillo JA, Jerling M, Bertilsson L "Interaction between caffeine and clozapine - comment." J Clin Psychopharmacol 15 (1995): 376-7
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: Clozapine, CloZAPine
Generic Name: acetaminophen / caffeine
Brand name: Excedrin Mild Headache, Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra, Excedrin Tension Headache Express
Synonyms: Excedrin Tension Headache
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clozapine Oral Suspension-Excedrin Tension Headache Geltab
- Clozapine Oral Suspension-ExeClear
- Clozapine Oral Suspension-ExeClear-C
- Clozapine Oral Suspension-ExeCof XP
- Clozapine Oral Suspension-Exefen IR Tablets
- Clozapine Oral Suspension-Exelon
- Excedrin Tension Headache Express Gels-Clozapine Orally Disintegrating Tablet
- Excedrin Tension Headache Express Gels-Clozapine Orally Disintegrating Tablets
- Excedrin Tension Headache Express Gels-Clozapine Tablets
- Excedrin Tension Headache Express Gels-Clozaril
- Excedrin Tension Headache Express Gels-CNJ-016 Injection
- Excedrin Tension Headache Express Gels-Co-Gesic