Clozapine Oral Suspension and Formerly available as Librium
Determining the interaction of Clozapine Oral Suspension and Formerly available as Librium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using cloZAPine together with chlordiazePOXIDE. Combining these medications can increase the effects of both medications. Depending on the doses you are using and the routes by which they are taken (orally or by injection), you may experience side effects such as extreme drowsiness, confusion, shallow breathing, low blood pressure, weak pulse, and incoordination. In severe cases, cardiac arrest, loss of consciousness, and even death have been reported. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR CLOSELY: Benzodiazepines and clozapine may have additive effects on respiratory and cardiovascular function. Ataxia, excessive salivation, hypotension, collapse, respiratory depression, respiratory arrest, loss of consciousness, cardiac arrest, and sudden death have been reported. The mechanism is unknown and causality has not been clearly determined.
MANAGEMENT: Caution is advised if concurrent therapy is necessary. Vital signs should be closely monitored.
- Grohmann R, Ruther E, Sassim N, Schmidt LG "Adverse effects of clozapine." Psychopharmacology (Berl) 99 (1989): s101-4
- Klimke A, Klieser E "Sudden death after intravenous application of lorazepam in a patient treated with clozapine." Am J Psychiatry 151 (1994): 780
- Cobb CD, Anderson CB, Seidel DR "Possible interaction between clozapine and lorazepam." Am J Psychiatry 148 (1991): 1606-7
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: Clozapine, CloZAPine
Generic Name: chlordiazepoxide
Brand name: Formerly available as Librium, Librium, Libritabs, Poxi, Mitran
Synonyms: formerly available as Librium, ChlordiazePOXIDE, Chlordiazepoxide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Clozapine Oral Suspension-Formoterol Capsules for Inhalation
- Clozapine Oral Suspension-Formoterol Fumarate
- Clozapine Oral Suspension-Formoterol inhalation
- Formerly available as Librium-Clozapine Orally Disintegrating Tablet
- Formerly available as Librium-Clozapine Orally Disintegrating Tablets
- Formerly available as Librium-Clozapine Tablets
- Formerly available as Librium-Clozaril
- Formerly available as Librium-CNJ-016 Injection
- Formerly available as Librium-Co-Gesic