Clozapine Oral Suspension and Lamictal

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cloZAPine together with lamoTRIgine may increase the effects of cloZAPine. Contact your doctor if you experience confusion, fainting, fast heart rate, drowsiness, drooling, difficulty breathing, and seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: A case report suggests that lamotrigine may increase the plasma concentrations of clozapine. The mechanism of interaction and a causal relationship have not been established. In the report, a 35-year-old man who had been stabilized on clozapine 400 mg/day for three years developed dizziness and sedation in association with a threefold increase in clozapine plasma concentration after two weeks of taking lamotrigine 100 mg/day. The dosage of lamotrigine was tapered over the next two weeks, and plasma clozapine levels returned to therapeutic levels.

MANAGEMENT: Pharmacologic response and plasma clozapine levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the clozapine dosage adjusted as necessary.

Clozapine Oral Suspension

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: Clozapine, CloZAPine

What is Clozapine Oral Suspension?

Lamictal

Generic Name: lamotrigine

Brand name: Lamictal, Lamictal ODT, Lamictal XR, Lamictal, Lamictal ODT, Lamictal XR, Subvenite, Lamictal CD, LaMICtal Starter Kit, LaMICtal ODT Patient Titration Kit, LaMICtal XR Patient Titration Kit, LamoTRIgine Starter Kit, Subvenite Starter Kit

Synonyms: n.a.

What is Lamictal?