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Clozapine Oral Suspension and Niacin SR

Determining the interaction of Clozapine Oral Suspension and Niacin SR and the possibility of their joint administration.

Check result:
Clozapine Oral Suspension <> Niacin SR
Relevance: 02.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A single case has been reported in which a man who was taking clozapine, nicotinic acid, L-tryptophan, and ascorbic acid developed a severe urticarial rash. Since the patient subsequently tolerated clozapine monotherapy, an interaction between clozapine and one of the other three drugs was suspected, but not proven. More information is needed.

References
  • Goumeniouk AD, Ancill RJ, MacEwan GW, Koczapski AB "A case of drug-drug interaction involving clozapine." Can J Psychiatry 36 (1991): 234-5
Clozapine Oral Suspension

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: Clozapine, CloZAPine

Niacin SR

Generic Name: niacin

Brand name: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niaspan ER, Slo-Niacin

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction