Clozapine Oral Suspension and Phenytoin Sodium, Prompt injection
Determining the interaction of Clozapine Oral Suspension and Phenytoin Sodium, Prompt injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using phenytoin together with cloZAPine may decrease the effects of cloZAPine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Several case reports suggest that phenytoin may reduce steady-state plasma concentrations of clozapine. Worsening of clinical status has been reported. Data exist for phenytoin, but this interaction may also occur with other hydantoins. The mechanism is unknown, but may be induction of CYP450 hepatic metabolism by phenytoin.
MANAGEMENT: If a hydantoin and clozapine must be used together, close observation for clinical and laboratory evidence of altered clozapine effect is recommended, especially when initiating, changing dosage, or discontinuing the hydantoin.
- Miller DD "Effect of phenytoin on plasma clozapine concentrations in two patients." J Clin Psychiatry 52 (1991): 23-5
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: Clozapine, CloZAPine
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clozapine Oral Suspension-Phenytoin Suspension
- Clozapine Oral Suspension-Philith
- Clozapine Oral Suspension-Phillips Milk of Magnesia
- Clozapine Oral Suspension-Phisohex
- Clozapine Oral Suspension-Phl-Fluoxetine
- Clozapine Oral Suspension-Phlemex
- Phenytoin Sodium, Prompt injection-Clozapine Orally Disintegrating Tablet
- Phenytoin Sodium, Prompt injection-Clozapine Orally Disintegrating Tablets
- Phenytoin Sodium, Prompt injection-Clozapine Tablets
- Phenytoin Sodium, Prompt injection-Clozaril
- Phenytoin Sodium, Prompt injection-CNJ-016 Injection
- Phenytoin Sodium, Prompt injection-Co-Gesic