Clozapine Orally Disintegrating Tablet and PCE Dispertab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cloZAPine together with erythromycin may increase the effects of cloZAPine. Contact your doctor if you experience confusion, fast heart rate, drowsiness, drooling, weak or shallow breathing, feeling like you might pass out, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant administration of some macrolides may result in decreased clearance of clozapine and increased risk of toxicity. The mechanism of this interaction is suspected to be inhibition of the CYP450 hepatic metabolism of clozapine.

MANAGEMENT: While clinical data are limited, clinical and laboratory monitoring may be appropriate whenever a macrolide is added to or withdrawn from therapy. Alternatively, azithromycin and dirithromycin may be considered, as they do not inhibit CYP450 and are not expected to affect clozapine metabolism. Patients should be advised to report symptoms such as somnolence, disorientation, slurred speech, seizures, uncontrolled movements, dizziness, irregular heartbeat, palpitations, fever, or hypersalivation to their physician.

Clozapine Orally Disintegrating Tablet

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: CloZAPine, Clozapine

What is Clozapine Orally Disintegrating Tablet?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?