Clozapine Orally Disintegrating Tablets and Famotidine and ibuprofen
Determining the interaction of Clozapine Orally Disintegrating Tablets and Famotidine and ibuprofen and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using famotidine together with cloZAPine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Famotidine may cause QTc prolongation. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. According to the manufacturer, prolongation of the QT interval has been reported very rarely in patients with impaired renal function whose dose/dosing interval of famotidine may not have been adjusted appropriately. In general, the risk of an individual agent or a combination of these agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Caution and clinical monitoring are recommended if famotidine is used in combination with other drugs that can prolong the QT interval. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
- "Product Information. Pepcid (famotidine)." Merck & Co, Inc, West Point, PA.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: Clozapine, CloZAPine
Generic Name: famotidine / ibuprofen
Brand name: Duexis
Synonyms: Ibuprofen and Famotidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clozapine Orally Disintegrating Tablets-Famotidine Chewable Tablets
- Clozapine Orally Disintegrating Tablets-Famotidine Injection
- Clozapine Orally Disintegrating Tablets-Famotidine Injection Solution
- Clozapine Orally Disintegrating Tablets-Famotidine Oral Suspension
- Clozapine Orally Disintegrating Tablets-Famotidine Tablets
- Clozapine Orally Disintegrating Tablets-Famotidine, Calcium Carbonate, and Magnesium Hydroxide
- Famotidine and ibuprofen-Clozapine Tablets
- Famotidine and ibuprofen-Clozaril
- Famotidine and ibuprofen-CNJ-016 Injection
- Famotidine and ibuprofen-Co-Gesic
- Famotidine and ibuprofen-Co-trimoxazole
- Famotidine and ibuprofen-Co-Veratrol