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Clozaril and Technivie

Determining the interaction of Clozaril and Technivie and the possibility of their joint administration.

Check result:

Clozaril <> Technivie

Relevance: 05.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cloZAPine together with ritonavir may increase the effects of cloZAPine. Contact your doctor if you experience confusion, fast heart rate, drowsiness, drooling, weak or shallow breathing, feeling like you might pass out, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ritonavir may theoretically increase the serum concentrations of clozapine. The proposed mechanism is ritonavir inhibition of clozapine metabolism via CYP450 3A4 and 2D6. However, no pharmacokinetic data are currently available. Clozapine is also metabolized by CYP450 1A2. Because it is a substrate for several different CYP450 enzymes, the risk of metabolic interactions caused by an effect on an individual isoform is thought to be minimized. Nevertheless, the manufacturer recommends caution during concomitant treatment of clozapine with other drugs that are inhibitors of these enzymes.

MANAGEMENT: Caution is advised if clozapine is prescribed in combination with ritonavir. Pharmacologic response to clozapine should be monitored more closely whenever ritonavir is added to or withdrawn from therapy in patients stabilized on their existing antipsychotic regimen, and the clozapine dosage adjusted as necessary.

References

"Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Penzak SR, Grimsley SR, Jann MW "Significant interactions with new antiretrovirals and psychotropic drugs." Ann Pharmacother 33 (1999): 1372-3

Clozaril

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: n.a.

What is Clozaril?

Technivie

Generic Name: ombitasvir / paritaprevir / ritonavir

Brand name: Technivie

Synonyms: n.a.

What is Technivie?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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