Cobicistat and darunavir and Phenytoin Sodium, Prompt injection
Determining the interaction of Cobicistat and darunavir and Phenytoin Sodium, Prompt injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using phenytoin together with darunavir. Using these medications together may cause darunavir to be less effective. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with carbamazepine, phenobarbital, phenytoin, or primidone may significantly reduce the plasma concentrations of darunavir. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of darunavir.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, darunavir should not be used in combination with carbamazepine, phenobarbital, phenytoin, or primidone.
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- Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9
- "Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: cobicistat / darunavir
Brand name: Prezcobix
Synonyms: Darunavir and Cobicistat
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cobicistat and darunavir-Phenytoin Suspension
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- Cobicistat and darunavir-Phisohex
- Cobicistat and darunavir-Phl-Fluoxetine
- Cobicistat and darunavir-Phlemex
- Phenytoin Sodium, Prompt injection-Cobicistat, darunavir, emtricitabine, and tenofovir
- Phenytoin Sodium, Prompt injection-Cobicistat, elvitegravir, emtricitabine, and tenofovir
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- Phenytoin Sodium, Prompt injection-Cobolin-M injection
- Phenytoin Sodium, Prompt injection-Cocaine (Topical)