Cobicistat, darunavir, emtricitabine, and tenofovir and Nimotop

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using niMODipine together with cobicistat is not recommended. Combining these medications may significantly increase the blood levels and effects of niMODipine. This may increase the risk of serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations and blood pressure lowering effect of nimodipine, which is primarily metabolized by CYP450 3A4 in the intestinal mucosa and liver.

MANAGEMENT: The use of nimodipine in combination with potent CYP450 3A4 inhibitors such as itraconazole, ketoconazole, posaconazole, voriconazole, conivaptan, nefazodone, delavirdine, protease inhibitors, and ketolide and certain macrolide antibiotics is considered contraindicated because of a risk of significant hypotension.

Cobicistat, darunavir, emtricitabine, and tenofovir

Generic Name: cobicistat / darunavir / emtricitabine / tenofovir alafenamide

Brand name: Symtuza

Synonyms: Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide

What is Cobicistat, darunavir, emtricitabine, and tenofovir?

Nimotop

Generic Name: nimodipine

Brand name: Nymalize, Nimotop

Synonyms: Nimotop (Oral)

What is Nimotop?