Cobimetinib and Donnatal Elixir
Determining the interaction of Cobimetinib and Donnatal Elixir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PHENobarbital may significantly reduce the blood levels of cobimetinib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent and moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of cobimetinib, which is primarily metabolized by the isoenzyme. Simulations using physiologically-based pharmacokinetic (PBPK) models suggest that cobimetinib exposures would decrease by 83% when coadministered with a potent CYP450 3A4 inducer and by 73% when coadministered with a moderate CYP450 3A4 inducer. The therapeutic efficacy of cobimetinib may be reduced.
MANAGEMENT: Concomitant use of cobimetinib with potent CYP450 3A4 inducers should generally be avoided.
- "Product Information. Cotellic (cobimetinib)." Genentech, South San Francisco, CA.
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Donnatal
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cobimetinib-Donnatal Tablets
- Cobimetinib-Donor Prep Kit
- Cobimetinib-Dopamine
- Cobimetinib-Dopamine and Dextrose
- Cobimetinib-Dopamine Hydrochloride
- Cobimetinib-Dopamine injection
- Donnatal Elixir-Cobimetinib Fumarate
- Donnatal Elixir-Cobolin-M injection
- Donnatal Elixir-Cocaine (Topical)
- Donnatal Elixir-Cocet Plus
- Donnatal Elixir-Codal-DM Syrup
- Donnatal Elixir-Codar AR