Cobimetinib Fumarate and Depakote

• Generic Name: cobimetinib
• Dosage Forms: n.a.
• Other Brand Names: Cotellic

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.

• Generic Name: divalproex sodium
• Dosage Forms: tablet, delayed release
• Other Brand Names: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote

Depakote (divalproex sodium) affects chemicals in the body that may be involved in causing seizures.

Depakote is used to treat various types of seizure disorders. This medicine is sometimes used together with other seizure medications.

Depakote is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches.

Depakote may also be used for purposes not listed in this medication guide.