Cobimetinib Fumarate and Dolor-Parche with Lidocaine Patch

• Generic Name: cobimetinib
• Dosage Forms: n.a.
• Other Brand Names: Cotellic

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.

• Generic Name: capsaicin / lidocaine / menthol / methyl salicylate topical
• Dosage Forms: topical patch
• Other Brand Names:

  LidoPro, Terocin, Transderm-iQ

Capsaicin, lidocaine, menthol, and methyl salicylate topical (for the skin) is a combination medicine used for temporary relief of muscle pain and soreness than may be related to arthritis, strains, backaches, or bruises.

Capsaicin, lidocaine, menthol, and methyl salicylate topical may also be used for purposes not listed in this medication guide.