Cobimetinib Fumarate and Ivermectin topical

• Generic Name: cobimetinib
• Dosage Forms: n.a.
• Other Brand Names: Cotellic

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.

• Generic Name: ivermectin topical
• Dosage Forms: n.a.
• Other Brand Names: Soolantra

Topical treatment of pediculosis capitis (head lice infestation) in adults and children ≥6 months of age.

AAP and others usually recommend topical treatment with OTC preparation of permethrin 1% or pyrethrins with piperonyl butoxide for initial treatment; other topical pediculicides (e.g., malathion 0.5%, benzyl alcohol 5%, spinosad 0.9%) recommended if OTC preparations ineffective or permethrin or pyrethrin resistance suspected. Oral ivermectin recommended as an alternative for infestations not responding to or resistant to topical agents.