Cobimetinib Fumarate and Keppra (Levetiracetam Injection)

• Generic Name: cobimetinib
• Dosage Forms: n.a.
• Other Brand Names: Cotellic

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.

• Generic Name: levetiracetam
• Dosage Forms: tablets and oral solution
• Other Brand Names: Keppra, Keppra XR, Roweepra, Spritam, Roweepra XR

• It is used to treat seizures.
• It may be given to you for other reasons. Talk with the doctor.