Cobimetinib Fumarate and Sudafed PE

• Generic Name: cobimetinib
• Dosage Forms: n.a.
• Other Brand Names: Cotellic

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.

• Generic Name: phenylephrine
• Dosage Forms: n.a.
• Other Brand Names: Sudafed PE, Contac-D, Lusonal, Nasop, Sudogest PE, Neo-Synephrine, Ah-Chew D, Despec-SF, Sudafed PE Quick Dissolve, Sudafed PE Extra Strength, Triaminic Thin Strips Nasal Congestion, Triaminic Toddler Congestion Thin Strips, Nasop12, Dimetapp Cold Drops, Triaminic Thin Strips Cold, Triaminic Thin Strips Infant Decongestant, Dimetapp Children's Cold & Allergy, Phenyl-T, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant, Vazculep, Sudafed PE Congestion

Sudafed PE (phenylephrine) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Sudafed PE is used to treat stuffy nose and sinus congestion caused by the common cold, hay fever, or other allergies.

Sudafed PE may also be used for purposes not listed in this medication guide.