Cobimetinib Fumarate and Zomacton
Determining the interaction of Cobimetinib Fumarate and Zomacton and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Somatropin may reduce the blood levels of cobimetinib, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of cobimetinib, which is primarily metabolized by the isoenzyme. Simulations using physiologically-based pharmacokinetic (PBPK) models suggest that cobimetinib exposures would decrease by 83% when coadministered with a potent CYP450 3A4 inducer and by 73% when coadministered with a moderate CYP450 3A4 inducer.
MANAGEMENT: The potential for diminished pharmacologic effects of cobimetinib should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.
- "Product Information. Cotellic (cobimetinib)." Genentech, South San Francisco, CA.
Generic Name: cobimetinib
Brand name: Cotellic
Synonyms: Cobimetinib
Generic Name: somatropin
Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cobimetinib Fumarate-Zometa
- Cobimetinib Fumarate-Zomig
- Cobimetinib Fumarate-Zomig (Zolmitriptan Nasal Spray)
- Cobimetinib Fumarate-Zomig (Zolmitriptan Tablets)
- Cobimetinib Fumarate-Zomig nasal
- Cobimetinib Fumarate-Zomig Nasal Spray
- Zomacton-Cobolin-M injection
- Zomacton-Cocaine (Topical)
- Zomacton-Cocet Plus
- Zomacton-Codal-DM Syrup
- Zomacton-Codar AR
- Zomacton-Codar D