Codeprex and DAUNOrubicin and Cytarabine

• Generic Name: chlorpheniramine / codeine
• Dosage Forms: extended-release suspension
• Other Brand Names: Codeprex, Codar AR, Tuzistra XR, Cotab A, Cotab AX, Notuss-AC, Z-Tuss AC, Zodryl AC 25, Zodryl AC 30, Zodryl AC 35, Zodryl AC 50, Zodryl AC 40, Zodryl AC 60, Zodryl AC 80, EndaCof-C, TL-Hist CM, Zodryl AC Adult, Lexuss 210, EndaCof-C, Tuxarin ER

Chlorpheniramine is an antihistamine. It blocks the effects of histamine in the body. Chlorpheniramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and colds. Codeprex is a combination of chlorpheniramine and codeine.

Codeprex is used to treat nasal congestion and coughs associated with allergies and the common cold.

Codeprex may also be used for purposes other than those listed in this medication guide.

• Generic Name: cytarabine liposomal / daunorubicin liposomal
• Dosage Forms: n.a.
• Other Brand Names: Vyxeos

Treatment of newly diagnosed therapy-related AML (t-AML; secondary AML) or AML with myelodysplasia-related changes (AML-MRC) in adults (designated an orphan drug by FDA for this use).

May be used for remission induction as well as consolidation therapy.

Evidence supporting efficacy is based principally on a study performed in patients with high-risk AML (i.e., patients >60 years of age with t-AML or AML-MRC).