Coditussin DAC and Reglan

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Narcotic pain medications like codeine may reduce the effects of metoclopramide. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact. In addition, combining these medications may increase nervous systemic side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with these medications, and also avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: By diminishing gastrointestinal motility, narcotic analgesics may antagonize the pharmacologic effects of gastrointestinal prokinetic agents. In addition, concomitant use may increase central nervous system effects such as sedation, dizziness, confusion, and mental depression.

MONITOR: Gastrointestinal prokinetic agents may alter the absorption characteristics of some controlled release narcotic analgesic preparations. In a study of 20 patients undergoing surgery, peak plasma concentration (Cmax) of morphine was reached more quickly in patients who received a 20 mg dose of sustained-release morphine with 20 mg metoclopramide compared to patients who received morphine alone, although the actual Cmax and systemic exposure (AUC) were not significantly altered. Both the degree and the rate of onset of sedation were also increased in the metoclopramide group, which may have been partially due to additive pharmacodynamic effects of the drugs. During chronic administration, however, the clinical relevance of this interaction may be diminished due to tolerance.

MANAGEMENT: The potential for reduced efficacy of gastrokinetic agents should be considered during coadministration with opioid analgesics. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their doctor if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Coditussin DAC

Generic Name: codeine / guaifenesin / pseudoephedrine

Brand name: Cheratussin DAC, Coditussin DAC, Guaifenesin DAC, Lortuss EX, Tricode GF, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Tussar SF, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Dihistine, Gua PC, Codahistine Expectorant, GuaiFENesin DAC Liquid, Novagest with Codeine, Codafed, Codafed Pediatric, Ambifed-G CD, Maxifed CD, Ambifed-G CDX, Ambifed CDX, Maxifed-G CDX, Maxifed CDX, Suttar-2, Suttar SF, Z-Tuss E

Synonyms: n.a.

What is Coditussin DAC?

Reglan

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: n.a.

What is Reglan?