Col-Probenecid and Diazepam
Determining the interaction of Col-Probenecid and Diazepam and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited clinical evidence suggests that benzodiazepine effects may have a more rapid onset and be more prolonged when probenecid is used concurrently. The mechanism may be related to interference with hepatic benzodiazepine conjugation. The clinical significance is unknown. Patients should be monitored for prolonged or excessive CNS depression. Benzodiazepine dosage reductions may be necessary.
- Dundee JW, Halliday NJ, McMurray TJ "Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam." Eur J Anaesthesiol 3 (1986): 247-51
- Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9
Generic Name: probenecid
Brand name: Benemid
Synonyms: Probenecid
Generic Name: diazepam
Brand name: Valium, Diastat, Diastat AcuDial, Diastat Pediatric, Diazepam Intensol, Zetran
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Col-Probenecid-Diazepam Autoinjector
- Col-Probenecid-Diazepam injection
- Col-Probenecid-Diazepam Intensol
- Col-Probenecid-Diazepam Oral Concentrate
- Col-Probenecid-Diazepam Oral Solution
- Col-Probenecid-Diazepam Oral Solution Concentrate
- Diazepam-Colace
- Diazepam-Colace (Docusate Capsules and Tablets)
- Diazepam-Colace (Docusate Liquid and Syrup)
- Diazepam-Colace Microenema
- Diazepam-Colace Pediatric
- Diazepam-Colazal