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Col-Probenecid and NegGram

Determining the interaction of Col-Probenecid and NegGram and the possibility of their joint administration.

Check result:

Col-Probenecid <> NegGram

Relevance: 07.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using probenecid together with nalidixic acid. This combination may reduce the effects of nalidixic acid in the treatment of urinary tract infections. Using these medications together can also cause drowsiness, weakness, dizziness, visual disturbances, and convulsions. An alternative antibiotic should be considered. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

GENERALLY AVOID: Coadministration with probenecid may reduce the efficacy of nalidixic acid in the treatment of urinary tract infections while increasing the risk of systemic side effects. The mechanism is probenecid inhibition of the urinary excretion of nalidixic acid via renal tubular secretion, resulting in decreased antibiotic concentration in the urine and increased concentration in the plasma. In a study consisting of two healthy volunteers, coadministration of a single 500 mg dose of nalidixic acid with a single 500 mg dose of probenecid resulted in a threefold increase in peak serum nalidixic acid levels at 8 hours postdose compared to administration of nalidixic acid alone. High plasma levels of nalidixic acid has been associated with metabolic acidosis and may cause central nervous system adverse effects such as drowsiness, weakness, dizziness, vertigo, visual disturbances, convulsions, increased intracranial pressure, and toxic psychosis.

MANAGEMENT: Alternatives to nalidixic acid should preferably be considered for the treatment of urinary tract infections in patients receiving probenecid. Nitrofurantoin and sulfamethoxazole-trimethoprim have not been reported to interact with probenecid and may be suitable choices depending on organism susceptibility.

References

"Product Information. NegGram (nalidixic acid)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Dash H, Mills J "Letter: Severe metabolic acidosis associated with nalidixic acid overdose." Ann Intern Med 84 (1976): 570-1

Col-Probenecid

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Col-Probenecid?

NegGram

Generic Name: nalidixic acid

Brand name:

Synonyms: n.a.

What is NegGram?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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