Col-Probenecid and Zyloprim
Determining the interaction of Col-Probenecid and Zyloprim and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Probenecid may increase the renal excretion of oxypurinol, the active metabolite of allopurinol, while allopurinol may inhibit probenecid metabolism. The clinical significance is unknown. Patients should be monitored for altered effects of both drugs.
- Tjandramaga TB, Cucinell SA, Israili ZH, et al "Observations on the disposition of probenecid in patients receiving allopurinol." Pharmacology 8 (1972): 259-72
- Kelley WN "Current therapy of gout and hyperuricemia." Hosp Pract 11 (1976): 69-76
- Elion GB, Yu TF, Gutman AB, Hitchings GH "Renal clearance of oxipurinol, the chief metabolite of allopurinol." Am J Med 45 (1968): 69-77
Generic Name: probenecid
Brand name: Benemid
Synonyms: Probenecid
Generic Name: allopurinol
Brand name: Zyloprim, Lopurin, Aloprim
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Col-Probenecid-Zymine Liquid
- Col-Probenecid-Zymine-D
- Col-Probenecid-Zyncof
- Col-Probenecid-Zypitamag
- Col-Probenecid-Zypram Cream
- Col-Probenecid-Zyprexa
- Zyloprim-Colace
- Zyloprim-Colace (Docusate Capsules and Tablets)
- Zyloprim-Colace (Docusate Liquid and Syrup)
- Zyloprim-Colace Microenema
- Zyloprim-Colace Pediatric
- Zyloprim-Colazal