Colchicine and probenecid and Dapsone (Systemic)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dapsone together with probenecid may increase the effects of dapsone. Contact your doctor if you experience nausea, vomiting, excitation, seizures, and bluish skin color. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Probenecid may inhibit the renal tubular secretion of dapsone. Serum dapsone levels and the risk of toxicity may be increased.

MANAGEMENT: Patients should be monitored for signs of dapsone toxicity, such as nausea, vomiting, hyperexcitability, seizures, muscle weakness, peripheral neuropathy, methemoglobinemia, or blood dyscrasias.

Colchicine and probenecid

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Colchicine and Probenecid

What is Colchicine and probenecid?

Dapsone (Systemic)

Generic Name: dapsone

Brand name:

Synonyms: Dapsone

What is Dapsone (Systemic)?