Colchicine and probenecid and Digoxin Oral Solution
Determining the interaction of Colchicine and probenecid and Digoxin Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using colchicine together with digoxin may elevate the blood levels of both drugs, increasing the risk of serious side effects that can affect your muscles, blood cells, nervous system, and multiple organs including the liver and kidneys. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if you experience irregular heartbeats, vision abnormalities, abdominal pain, nausea, vomiting, diarrhea, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of digoxin and colchicine may increase the plasma concentrations of both drugs. The proposed mechanism is competitive inhibition of P-glycoprotein (P-gp) efflux transporter in the intestine, renal proximal tubule and liver, resulting in increased drug absorption and decreased excretion. Rhabdomyolysis, which is a toxic effect of colchicine, has been reported.
MANAGEMENT: Caution is advised if digoxin and colchicine are used in combination. Serum digoxin levels should be monitored more closely whenever colchicine is added to or withdrawn from therapy, and the digoxin dosage adjusted as necessary. Patients should be advised to notify their physician if they experience signs and symptoms of digoxin toxicity (e.g., irregular heartbeats, slow pulse, nausea, anorexia, visual changes) or colchicine toxicity (e.g., abdominal pain, nausea, vomiting, diarrhea, fatigue, myalgia, asthenia, hyporeflexia, paresthesia, numbness).
- "Product Information. Colcrys (colchicine)." AR Scientific Inc, Philadelphia, PA.
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Colchicine and Probenecid
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Colchicine and probenecid-Digoxin oral/injection
- Colchicine and probenecid-Digoxin Tablets
- Colchicine and probenecid-Dihydro CP Syrup
- Colchicine and probenecid-Dihydrocodeine BPM Phenyleph HCl
- Colchicine and probenecid-Dihydrocodeine, Aspirin, and Caffeine
- Colchicine and probenecid-Dihydroergotamine
- Digoxin Oral Solution-Colchicine Capsules
- Digoxin Oral Solution-Colchicine Oral, Intravenous
- Digoxin Oral Solution-Colchicine Tablets
- Digoxin Oral Solution-Colcrys
- Digoxin Oral Solution-Cold & Allergy Relief
- Digoxin Oral Solution-Cold & Cough Childrens