Colchicine and probenecid and Hivid

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using zalcitabine together with probenecid may increase the effects of zalcitabine. Contact your doctor if you experience numbness, tingling, severe nausea and vomiting, diarrhea, abdominal pain, severe fatigue, jaundice (yellowing of the skin), unusual bleeding or bruising. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Probenecid may increase plasma concentrations and decrease clearance of zalcitabine. The mechanism may be inhibition of renal tubular secretion of zalcitabine.

MANAGEMENT: Close clinical monitoring for evidence of zalcitabine toxicity (peripheral neuropathy, pancreatitis, lactic acidosis, hepatotoxicity) is recommended when these drugs are used together. In addition, a reduction in zalcitabine dosage may be warranted. Patients should be advised to promptly notify their physician if they experience numbness, tingling, severe nausea and vomiting, diarrhea, abdominal pain, severe fatigue, jaundice, or unusual bleeding or bruising.

Colchicine and probenecid

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Colchicine and Probenecid

What is Colchicine and probenecid?

Hivid

Generic Name: zalcitabine

Brand name:

Synonyms: n.a.

What is Hivid?