Colchicine and probenecid and Moexipril
Determining the interaction of Colchicine and probenecid and Moexipril and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Probenecid may decrease the renal clearance of ACE inhibitors. Plasma levels and antihypertensive effects of ACE inhibitors may be increased. Data are available for captopril only. Although no adverse effects have been reported in study subjects, the patient's blood pressure should be monitored during coadministration.
- Drummer OH, Thompson J, Hooper R, Jarrott B "Effect of probenecid on the disposition of captopril and captopril dimer in the rat." Biochem Pharmacol 34 (1985): 3347-51
- Singhvi SM, Duchin KL, Willard DA, et al "Renal handling of captopril: effect of probenecid." Clin Pharmacol Ther 32 (1982): 182-9
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Colchicine and Probenecid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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