Colchicine and probenecid and Valcyte

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using valGANciclovir together with probenecid may increase the effects of valGANciclovir. Contact your doctor if you experience seizures, diarrhea, decreased urine production, jaundice (yellowing of the skin or eyes), abdominal pain, paleness, fever and chills. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration of probenecid and ganciclovir may result in elevated plasma concentrations of ganciclovir. In 10 subjects with HIV infection, probenecid (500 mg orally every 6 hours) increased the peak plasma concentration and area under the concentration-time curve of ganciclovir (1 gram orally every 8 hours) by an average of 40% and 53%, respectively. Renal clearance decreased an average of 22%. The mechanism of the interaction is competitive inhibition of ganciclovir renal tubular secretion by probenecid.

MANAGEMENT: Caution is advised if ganciclovir or its prodrug, valganciclovir, must be used concomitantly with probenecid. Close monitoring for toxicities associated with ganciclovir such as myelosuppression is recommended during concurrent therapy.

Colchicine and probenecid

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Colchicine and Probenecid

What is Colchicine and probenecid?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?