Colchicine Tablets and Ketoconazole (Systemic)
Determining the interaction of Colchicine Tablets and Ketoconazole (Systemic) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using colchicine together with ketoconazole is not recommended. Combining these medications may increase the blood levels of colchicine to dangerous levels, increasing the risk of serious side effects that can affect your muscles, blood cells, nervous system, and multiple organs including the liver and kidneys. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 such as ketoconazole may significantly increase the serum concentrations of colchicine, which is primarily metabolized by the isoenzyme. Clinical toxicity including myopathy, neuropathy, multiorgan failure, and pancytopenia may occur.
MANAGEMENT: Due to the risk of life-threatening and fatal toxicity, concomitant use of colchicine with ketoconazole is considered contraindicated.
- "Product Information. Colcrys (colchicine)." AR Scientific Inc, Philadelphia, PA.
- "Colchicine: serious interactions." Prescrire Int 17 (2008): 151-3
- "Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ. (1992):
Generic Name: colchicine
Brand name: Colcrys, Mitigare
Synonyms: Colchicine
Generic Name: ketoconazole
Brand name: Nizoral
Synonyms: Ketoconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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