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Cold Medicine Plus and Diflunisal

Determining the interaction of Cold Medicine Plus and Diflunisal and the possibility of their joint administration.

Check result:

Cold Medicine Plus <> Diflunisal

Relevance: 17.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Acetaminophen serum concentrations may be elevated by as much as 50% during concomitant therapy with diflunisal in normal subjects. The clinical significance of this finding is unknown. Because elevated acetaminophen levels are associated with hepatotoxicity, the manufacturer recommends caution when this combination is used.

References

"Product Information. Dolobid (diflunisal)." Merck & Co, Inc, West Point, PA.

Cold Medicine Plus

Generic Name: acetaminophen / chlorpheniramine / pseudoephedrine

Brand name: Cold Medicine Plus, EQ Cold Plus, Alka-Seltzer Plus Cold Liquigel, Comtrex Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Kolephrin, Sinutab Ex-Strength, Theraflu Maximum Strength, Singlet, Simplet, Tricom, Theraflu Flu and Cold Medicine Powder, Codimal, Tylenol Gelcap Allergy Sinus, Theraflu Sore Throat Maximum Strength, Allerest Sinus, Tylenol Cold-Child, Tylenol Allergy Sinus Caplet, Tylenol Allergy Sinus Geltab, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Sinarest, Children's Tylenol Cold Multi-Symptom, Tylenol Allergy Sinus Gelcap, Children's Tylenol Cold, Triaminicin, Sinutab Maximum Strength Caplets, Sinutab Maximum Strength Non-Drowsy, Actifed Cold & Sinus, Theraflu Cold & Sore Throat, Theraflu Flu & Sore Throat, Allergy Sinus Maximum Strength, Complete Sinus Relief, Sinadrin PE Complete Sinus Relief

Synonyms: n.a.

What is Cold Medicine Plus?

Diflunisal

Generic Name: diflunisal

Brand name: Dolobid

Synonyms: n.a.

What is Diflunisal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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