Colesevelam and Prograf (Tacrolimus Granules for Suspension)
Determining the interaction of Colesevelam and Prograf (Tacrolimus Granules for Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Colesevelam may interfere with the absorption of tacrolimus when these medications are taken at the same time. This may reduce the blood levels and effects of tacrolimus. To prevent or minimize the interaction, tacrolimus should be taken at least four hours before the colesevelam dose. Contact your doctor if your condition changes or your symptoms worsen during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Colesevelam may decrease the gastrointestinal absorption of coadministered drugs. Approximately 20% to 40% reductions in systemic exposure (AUC) and 10% to 45% reductions in peak plasma concentration (Cmax) have been reported for cyclosporine, ethinyl estradiol, glimepiride, glyburide, levothyroxine, olmesartan, and sustained-release verapamil during coadministration with colesevelam. Significant pharmacokinetic changes were not observed when the drugs were administered 4 hours prior to colesevelam. During postmarketing use of colesevelam, there have been rare reports of suspected interaction with phenytoin, as evidenced by increased seizure activity or decreased phenytoin levels. Elevated thyroid-stimulating hormone (TSH) levels have also been observed in patients receiving thyroid hormone replacement therapy.
MANAGEMENT: In general, drugs with a narrow therapeutic index as well as those that have been shown to interact with colesevelam should be administered at least 4 hours before the colesevelam dose. Clinical and laboratory monitoring of drug levels and effects should be considered.
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Generic Name: colesevelam
Brand name: Welchol, Colesevelam Hydrochloride
Synonyms: n.a.
Generic Name: tacrolimus
Brand name: Prograf, Astagraf XL, Envarsus XR, Hecoria
Synonyms: Prograf
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Colesevelam-Prograf (Tacrolimus Injection)
- Colesevelam-Prograf Intravenous
- Colesevelam-Prohance
- Colesevelam-ProHance Injection
- Colesevelam-Prohist LQ
- Colesevelam-Prolensa
- Prograf (Tacrolimus Granules for Suspension)-Colesevelam Hydrochloride
- Prograf (Tacrolimus Granules for Suspension)-Colesevelam Oral Suspension
- Prograf (Tacrolimus Granules for Suspension)-Colesevelam Tablets
- Prograf (Tacrolimus Granules for Suspension)-Colestid
- Prograf (Tacrolimus Granules for Suspension)-Colestid (Colestipol Granules)
- Prograf (Tacrolimus Granules for Suspension)-Colestid (Colestipol Tablets)