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Colesevelam Hydrochloride and Teriflunomide

Determining the interaction of Colesevelam Hydrochloride and Teriflunomide and the possibility of their joint administration.

Check result:

Colesevelam Hydrochloride <> Teriflunomide

Relevance: 08.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Colesevelam may interfere with the absorption of teriflunomide, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with bile acid sequestrants may decrease the plasma concentrations of teriflunomide. The proposed mechanism involves an interruption of enterohepatic recycling and/or gastrointestinal dialysis of teriflunomide.

MANAGEMENT: Concomitant administration of these drugs is not recommended unless an accelerated elimination is desired. An alternative to bile acid sequestrants should be considered as separating drug administration times is unlikely to be effective at avoiding the interaction.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Colesevelam Hydrochloride

Generic Name: colesevelam

Brand name: Welchol, Colesevelam Hydrochloride

Synonyms: Colesevelam

What is Colesevelam Hydrochloride?

Teriflunomide

Generic Name: teriflunomide

Brand name: Aubagio

Synonyms: n.a.

What is Teriflunomide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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