Colestid (Colestipol Tablets) and Mycophenolate Mofetil Injection
Determining the interaction of Colestid (Colestipol Tablets) and Mycophenolate Mofetil Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Colestipol may interfere with the absorption of mycophenolate mofetil, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with bile acid sequestrants or activated charcoal may decrease the bioavailability of mycophenolic acid. In 12 healthy volunteers, pretreatment with cholestyramine (4 g three times a day for 4 days) decreased the systemic exposure (AUC) of mycophenolic acid (from mycophenolate mofetil 1.5 g single dose) by 40% compared to administration of mycophenolate mofetil alone. The proposed mechanism is interruption of enterohepatic recirculation due to binding of recirculating mycophenolic acid glucuronide (a product of the first-pass metabolism of mycophenolic acid) with cholestyramine in the intestine. Some degree of enterohepatic recirculation is also anticipated following intravenous administration of mycophenolate mofetil, thus the interaction is not limited to the oral route.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant blood levels, mycophenolic acid products should not be administered with cholestyramine or other agents that may interfere with enterohepatic recirculation or bind bile acids (e.g., activated charcoal).
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
Generic Name: colestipol
Brand name: Colestid, Colestid Flavored
Synonyms: Colestid
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: Mycophenolate, Mycophenolate mofetil (oral/injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Colestid (Colestipol Tablets)-Mycophenolate Mofetil Injection Solution
- Colestid (Colestipol Tablets)-Mycophenolate Mofetil Oral Suspension
- Colestid (Colestipol Tablets)-Mycophenolate mofetil oral/injection
- Colestid (Colestipol Tablets)-Mycophenolate Mofetil Tablets
- Colestid (Colestipol Tablets)-Mycophenolate sodium
- Colestid (Colestipol Tablets)-Mycophenolate Suspension
- Mycophenolate Mofetil Injection-Colestid Flavored
- Mycophenolate Mofetil Injection-Colestid Oral Suspension
- Mycophenolate Mofetil Injection-Colestipol
- Mycophenolate Mofetil Injection-Colestipol Granules
- Mycophenolate Mofetil Injection-Colestipol Hydrochloride
- Mycophenolate Mofetil Injection-Colestipol Suspension