Colestipol Tablets and NP Thyroid 120
Determining the interaction of Colestipol Tablets and NP Thyroid 120 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Taking the thyroid desiccated and colestipol doses too close together may interfere with the absorption of thyroid desiccated and reduce its effectiveness. To prevent or minimize the interaction, thyroid desiccated and colestipol should be taken at least four hours apart. Contact your doctor if you experience signs and symptoms of reduced thyroid function such as fatigue; sluggishness; constipation; depression; hoarseness; unexplained weight gain; sensitivity to cold; pale, dry skin; muscle aches, weakness, or tenderness; joint pain, stiffness, or swelling; heavier than normal menstruation periods; or brittle fingernails and hair. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Bile acid sequestrants may bind to and decrease the gastrointestinal absorption of thyroid hormones. There have been isolated reports of worsening hypothyroidism and increased TSH levels following the addition of cholestyramine in patients receiving thyroid replacement therapy.
MANAGEMENT: Thyroid hormone preparations and bile acid sequestrants should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended during coadministration, since adjusting the dosing interval may not completely prevent the interaction.
- Cashin-Hemphill L, Spencer CA, Nicoloff JT, Blankenhorn DH, Nessim SA, Chin HP, Lee NA "Alterations in serum thyroid hormonal indices with colestipol-niacin therapy." Ann Intern Med 107 (1987): 324-9
- "Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical, Abbott Park, IL.
- Harmon SM, Seifert CF "Levothyroxine-cholestyramine interaction reemphasized." Ann Intern Med 115 (1991): 658-9
- Northcutt RC, Stiel JN, Hollifield JW, Stant EG "The influence of cholestyramine on thyroxine absorption." JAMA 208 (1969): 1857-61
- "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
Generic Name: colestipol
Brand name: Colestid, Colestid Flavored
Synonyms: Colestipol
Generic Name: thyroid desiccated
Brand name: Armour Thyroid, Nature-Throid, Westhroid, Thyroid Porcine, NP Thyroid, WP Thyroid
Synonyms: Thyroid, Desiccated
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Colestipol Tablets-NP Thyroid 15
- Colestipol Tablets-NP Thyroid 30
- Colestipol Tablets-NP Thyroid 60
- Colestipol Tablets-NP Thyroid 90
- Colestipol Tablets-NPD Ophthalmic Ointment
- Colestipol Tablets-Nplate
- NP Thyroid 120-Colidrops
- NP Thyroid 120-Colistimethate
- NP Thyroid 120-Colistimethate Injection
- NP Thyroid 120-Colistimethate Sodium
- NP Thyroid 120-Colistin, hydrocortisone, neomycin, and thonzonium otic
- NP Thyroid 120-Colistin, neomycin, thonzonium, and hydrocortisone Otic