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Colistimethate Injection and Mivacron

Determining the interaction of Colistimethate Injection and Mivacron and the possibility of their joint administration.

Check result:

Colistimethate Injection <> Mivacron

Relevance: 02.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using mivacurium together with colistimethate can prolong the effects of mivacurium. You should be closely monitored for prolonged breathing cessation and respiratory paralysis after use of colistimethate. You may need special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Like other polypeptide antibiotics, colistimethate may prolong apnea and respiratory paralysis after use of neuromuscular blocking agents. The mechanism may be related to decreased intracellular potassium or decreased ionized serum calcium.

MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade. Intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.

References

Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Vecuronium Bromide (vecuronium)." Hospira Inc, Lake Forest, IL.
Cerner Multum, Inc "ANVISA Bulário Eletrônico. Available from: URL: http://www.anvisa.gov.br/datavisa/fila_bula/index.asp." O 0 (2015):
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
"Product Information. Coly-Mycin M Parenteral (colistimethate)." Parke-Davis, Morris Plains, NJ.
Huang KC, Heise A, Shrader AK, Tsueda K "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg 71 (1990): 194-6
Kronenfeld MA, Thomas SJ, Turndorf H "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology 65 (1986): 93-4
"Product Information. Rocuronium Bromide (rocuronium)." Hospira Inc, Lake Forest, IL.

Colistimethate Injection

Generic Name: colistimethate

Brand name: Coly Mycin M

Synonyms: Colistimethate

What is Colistimethate Injection?

Mivacron

Generic Name: mivacurium

Brand name: Mivacron

Synonyms: n.a.

What is Mivacron?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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