Collagenase clostridium histolyticum and Fentora

• Generic Name: collagenase clostridium histolyticum
• Dosage Forms: n.a.
• Other Brand Names: Xiaflex

Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.

Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Collagenase clostridium histolyticum is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.

Collagenase clostridium histolyticum is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking collagenase clostridium histolyticum.

Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.

• Generic Name: fentanyl
• Dosage Forms: buccal tablet, sublingual tablet
• Other Brand Names: Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze

Fentora (fentanyl) is an opioid pain medication. An opioid is sometimes called a narcotic.

Fentora buccal tablets are used to treat "breakthrough" cancer pain that is not controlled by other medicines.

The tablets are used in the mouth but not swallowed whole. The tablet is placed inside the mouth between the cheek and gum (buccal) OR on the floor of your mouth, under your tongue (sublingual).

Fentora is not for treating pain that is not cancer-related.