Collagenase Santyl and Levothyroxine

• Generic Name: collagenase clostridium histolyticum
• Dosage Forms: ointment
• Other Brand Names: Xiaflex

Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.

Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Collagenase clostridium histolyticum is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.

Collagenase clostridium histolyticum is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking collagenase clostridium histolyticum.

Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.

• Generic Name: levothyroxine
• Dosage Forms: n.a.
• Other Brand Names: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol

Levothyroxine is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body's energy and metabolism.

Levothyroxine is given when your thyroid does not produce enough of this hormone on its own.

Levothyroxine is used to treat hypothyroidism (low thyroid hormone). It is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.

There are many brands and forms of levothyroxine available. Not all brands are listed on this leaflet.