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Collagenase topical and Flamazine Topical

Determining the interaction of Collagenase topical and Flamazine Topical and the possibility of their joint administration.

Check result:
Collagenase topical <> Flamazine Topical
Relevance: 05.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using silver sulfADIAZINE topical together with collagenase topical. Silver sulfADIAZINE topical can reduce the effects of collagenase topical when applied to the same site. Silver sulfADIAZINE topical should generally not be used on wounds treated with collagenase topical unless specifically directed by your doctor. If silver sulfADIAZINE topical has been used, the site should be carefully cleansed by repeated washings with normal saline before application of collagenase topical. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The enzymatic activity of collagenase may be adversely affected by heavy metal ions such as mercury and silver, which are found in some antiseptics. The mechanism of interaction has not been described.

MANAGEMENT: Topical preparations containing heavy metals such as silver and mercury should not be used on wounds treated with collagenase. When it is suspected such products have been used, the site should be carefully cleansed by repeated washings with normal saline before application of collagenase.

References
  • "Product Information. Santyl (collagenase topical)." Knoll Pharmaceutical Company, Mount Olive, NJ.
Collagenase topical

Generic Name: collagenase topical

Brand name: Santyl

Synonyms: Collagenase (Topical)

Flamazine Topical

Generic Name: silver sulfadiazine topical

Brand name: Silvadene, SSD, Thermazene, SSD AF

Synonyms: Silver sulfadiazine topical, Silver Sulfadiazine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle