Cometriq and Klofensaid II
Determining the interaction of Cometriq and Klofensaid II and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using diclofenac topical together with cabozantinib may increase the risk of bleeding. Nonsteroidal anti-inflammatory drugs including those in topical preparations such as eye drop and analgesic cream/ointment/gel can interfere with clotting and cause bleeding, especially when used regularly or for prolonged periods. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Systemically and topically administered nonsteroidal anti-inflammatory drugs (NSAIDs) may potentiate the risk of bleeding in patients treated with anticoagulants and other drugs that affect hemostasis such as platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia. The pharmacologic effects of NSAIDs that contribute to this interaction include prolongation of prothrombin time and inhibition of platelet adhesion and aggregation.
MANAGEMENT: Caution is advised if NSAIDs are used in combination with other drugs that affect hemostasis. Close clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their doctor, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- "Product Information. Acular (ketorolac)." Allergan Inc, Irvine, CA.
- "Product Information. Xibrom (bromfenac ophthalmic)." ISTA Pharmaceuticals, Irvine, CA.
- "Product Information. Nevanac (nepafenac ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.
Generic Name: cabozantinib
Brand name: Cometriq, Cabometyx
Synonyms: n.a.
Generic Name: diclofenac topical
Brand name: Klofensaid II, Pennsaid, Vopac MDS, Xrylix, DST Plus Pak, Solaraze, Voltaren Topical, Diclozor, Voltaren, Flector Patch, Flector, Licart
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cometriq-Klonopin
- Cometriq-Klonopin Wafer
- Cometriq-Klonopin Wafers
- Cometriq-Klor-Con
- Cometriq-Klor-Con M
- Cometriq-Klor-Con Powder
- Klofensaid II-Comfort Pac w/Tizanidine
- Klofensaid II-Comfort Pac with Cyclobenzaprine
- Klofensaid II-Comfrey
- Klofensaid II-Commit
- Klofensaid II-Compazine
- Klofensaid II-Compazine Rectal