Compazine Rectal and Xylocaine With Epinephrine
Determining the interaction of Compazine Rectal and Xylocaine With Epinephrine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:EPINEPHrine may be ineffective for the treatment of excessively low blood pressure, shock, or collapse if you are receiving prochlorperazine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Phenothiazines and other neuroleptics may inhibit or reverse the pressor effect of adrenaline (epinephrine), dopamine, and similar vasoconstrictors. Many of these agents, including the atypical antipsychotics, exhibit alpha-1 adrenergic blocking activity and produce hypotension as an adverse effect. Use of adrenaline or dopamine for drug-induced hypotension and circulatory collapse in patients receiving neuroleptic therapy may cause a paradoxical further lowering of blood pressure, since beta stimulation may worsen hypotension in the setting of alpha blockade.
MANAGEMENT: Adrenaline, dopamine, and similar vasoconstrictors should not be used to treat drug-induced hypotension and circulatory collapse in patients taking phenothiazines or other neuroleptic agents. Alternative vasopressor agents such as metaraminol, noradrenaline (norepinephrine), or phenylephrine should be considered, and vital signs closely monitored.
- "Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.
- Sletten IW, Lang WJ, Brown ML, Ballou SR, Gershon S "Chronic chlorpromazine administration: some pharmacological and psychological effects in man." Clin Pharmacol Ther 6 (1965): 575-86
- "Product Information. Loxitane C Oral Concentrate (loxapine)" Watson Laboratories Inc, Corona, CA.
- "Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
- Gonzalez ER "Catecholamine selection for vasopressor-dependent patients." Clin Pharm 7 (1988): 493, 496
- "Product Information. Abilify (aripiprazole)." Bristol-Myers Squibb, Princeton, NJ.
- "Product Information. Thorazine (chlorpromazine)." SmithKline Beecham, Philadelphia, PA.
- "Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
- Goulet JP, Perusse R, Turcotte JY "Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions." Oral Surg Oral Med Oral Pathol 74 (1992): 692-7
- "Product Information. Invega (paliperidone)." Janssen Pharmaceuticals, Titusville, NJ.
- Ginsburg J, Duff RS "Effect of chlorpromazine on adrenaline vasoconstriction in man." Br J Pharmacol 11 (1956): 180-5
- "Product Information. Seroquel (quetiapine)." Zeneca Pharmaceuticals, Wilmington, DE.
- "Product Information. Navane (thiothixene)." Roerig Division, New York, NY.
- "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.
- Lear E, Chiron AE, Pallin IM "A clinical study of mechanisms of action of chlorpromazine." JAMA 163 (1957): 30-6
- "Product Information. Moban (molindone)." Gate Pharmaceuticals, Sellersville, PA.
- Foster CA, O'Mullane EJ, Gaskell P, Churchill-Davidson HC "Chlorpromazine: a study of its action on the circulation in man." Lancet 2 (1954): 614-7
Generic Name: prochlorperazine
Brand name: Compazine, Compro
Synonyms: Compazine
Generic Name: epinephrine / lidocaine
Brand name: D-Care 100X, Lignospan Forte, Lignospan Standard, Xylocaine MPF With Epinephrine, Xylocaine With Epinephrine
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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