Complera and Pepcid

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

By reducing the acidity level in the stomach, famotidine can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. To minimize the risk of interaction, famotidine should be taken at least 12 hours before or 4 hours after you take rilpivirine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Coadministration with H2-receptor antagonists may significantly decrease the oral bioavailability of rilpivirine. The proposed mechanism involves a pH-dependent reduction in dissolution and absorption of rilpivirine, which is poorly soluble over a wide pH range. When a single 40 mg dose of famotidine was administered 2 hours before a single 150 mg dose of rilpivirine to 23 study subjects, mean rilpivirine peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 85% and 76%, respectively, compared to rilpivirine administered alone. By contrast, when the dose of famotidine was administered either 12 hours before or 4 hours after the rilpivirine dose, no clinically significant changes in rilpivirine Cmax and AUC were observed.

MANAGEMENT: To minimize the risk of reduced viral susceptibility and resistance development associated with subtherapeutic levels of rilpivirine, H2-receptor antagonists should be administered at least 12 hours before or 4 hours after the rilpivirine dose.

Complera

Generic Name: emtricitabine / rilpivirine / tenofovir

Brand name: Complera, Odefsey

Synonyms: n.a.

What is Complera?

Pepcid

Generic Name: famotidine

Brand name: Pepcid, Heartburn Relief, Pepcid AC, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension

Synonyms: n.a.

What is Pepcid?