Complera and Sodium Bicarbonate Infant Injection
Determining the interaction of Complera and Sodium Bicarbonate Infant Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:By reducing the acidity level in the stomach, sodium bicarbonate can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. To minimize the risk of interaction, sodium bicarbonate should be taken at least 2 hours before or 4 hours after you take rilpivirine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of rilpivirine. The proposed mechanism involves a pH-dependent reduction in dissolution and absorption of rilpivirine, which is poorly soluble over a wide pH range. The interaction has not been studied specifically with antacids, but has been reported for H2-receptor antagonists and proton pump inhibitors.
MANAGEMENT: To minimize the risk of reduced viral susceptibility and resistance development associated with subtherapeutic levels of rilpivirine, antacids or other medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) should be administered at least 2 hours before or 4 hours after the rilpivirine dose.
- "Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.
Generic Name: emtricitabine / rilpivirine / tenofovir
Brand name: Complera, Odefsey
Synonyms: n.a.
Generic Name: sodium bicarbonate
Brand name: Neut
Synonyms: Sodium bicarbonate, Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Complera-Sodium Bicarbonate Injection
- Complera-Sodium bicarbonate Oral, Intravenous, Subcutaneous
- Complera-Sodium Bicarbonate Tablets
- Complera-Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt
- Complera-Sodium biphosphate and sodium phosphate
- Complera-Sodium biphosphate and sodium phosphate rectal
- Sodium Bicarbonate Infant Injection-Complete Allergy
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- Sodium Bicarbonate Infant Injection-Compliments Bismuth - Regular Strength
- Sodium Bicarbonate Infant Injection-Compound W
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