Complera and Sporanox (Itraconazole Oral Solution)
Determining the interaction of Complera and Sporanox (Itraconazole Oral Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using rilpivirine together with itraconazole. Combining these medications may increase the blood levels and effects of rilpivirine. At the same time, itraconazole levels may decrease, which may make the medication less effective. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of oral azole antifungal agents and supratherapeutic doses of rilpivirine (150 mg daily) may increase the plasma concentrations of rilpivirine and may modestly decrease the plasma concentrations of the antifungal. The mechanism is inhibition of CYP450 3A4-mediated metabolism by the antifungal agent and induction of metabolism by rilpivirine.
MANAGEMENT: Patients should be monitored for breakthrough fungal infections during concomitant therapy. A rilpivirine dose adjustment is not required.
- "Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.
Generic Name: emtricitabine / rilpivirine / tenofovir
Brand name: Complera, Odefsey
Synonyms: n.a.
Generic Name: itraconazole
Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura
Synonyms: Sporanox
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Complera-Sporanox Capsules
- Complera-Sporanox injection
- Complera-Sporanox PulsePak
- Complera-Sportsmed Topical
- Complera-Spravato
- Complera-Spravato (56 MG Dose)
- Sporanox (Itraconazole Oral Solution)-Complete Allergy
- Sporanox (Itraconazole Oral Solution)-Complete-RF Prenatal
- Sporanox (Itraconazole Oral Solution)-Complex A Tretinoin Cream
- Sporanox (Itraconazole Oral Solution)-Compliments Bismuth - Regular Strength
- Sporanox (Itraconazole Oral Solution)-Compound W
- Sporanox (Itraconazole Oral Solution)-Compound W One-Step Wart Remover Topical