Compro and Ismelin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using prochlorperazine together with guanethidine. Taking these medicaions together can make guanethidine less effective. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Phenothiazines may inhibit the antihypertensive effect of guanethidine, probably through inhibition of guanethidine neuronal uptake. No data are available for guanadrel, but a similar interaction is suspected. Other adrenergic neurone blockers may also interact.

MANAGEMENT: This combination should generally be avoided. An alternative antihypertensive regimen may be necessary for patients who must take phenothiazine antipsychotics. If patients do receive a phenothiazine with an adrenergic neurone blocker, their blood pressure should be monitored closely. The dosage of the antihypertensive may require adjustment.

Compro

Generic Name: prochlorperazine

Brand name: Compro, Compazine

Synonyms: Compro (rectal)

What is Compro?

Ismelin

Generic Name: guanethidine

Brand name:

Synonyms: Ismelin (Oral)

What is Ismelin?